Romosozumab: Amgen’s New Sclerostin Inhibitor

Romosozumab is a new Sclerostin Inhibitor from Amgen. Specifically it is a humanized monoclonal antibody that targets sclerostin for the treatment of osteoporosis. According to Wikipedia:

Its use has increased bone growth in preclinical trials in osteoporotic rats and monkeys. In a Phase I study, a single dose of anti-sclerostin antibody from Amgen (Romosozumab) increased bone density in the hip and spine in healthy men and postmenopausal women and the drug was well tolerated. In a Phase II trial, one year of the antibody treatment in osteoporotic women increased bone density more than bisphosphonate and teriparatide treatment….

The Amgen drug is expected to be on the market in 2017 and is predicted to be the gold standard in osteoporosis treatment by 2021.

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