Rutin Inhibits Osteoclasts by Decreasing ROS and TNF-alpha by Inhibiting NF-kappaB

Abstract

Rutin inhibits osteoclast formation by decreasing reactive oxygen species and TNF-alpha by inhibiting activation of NF-kappaB.

Rutin, a glycoside of flavonol, inhibits osteoclast formation induced by receptor activator of NF-kappaB ligand (RANKL) in bone marrow-derived macrophages. It reduces reactive oxygen species produced by RANKL and its inhibitory effect results from reduced levels of TNF-alpha. Rutin also lowers NF-kappaB activation in response to RANKL.

Kyung TW, Lee JE, Shin HH, Choi HS
Exp. Mol. Med. Feb 2008
PMID: 18305398 | Free Full Text

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